Author Contributions: Drs Moses and Dorsey
had full access to all of the data in the study and take responsibility for
the integrity of the data and the accuracy of the data analysis.
Study concept and design: Moses, Matheson,
Acquisition of data: Moses, Dorsey, Matheson.
Analysis and interpretation of data: Moses,
Dorsey, Matheson, Thier.
Drafting of the manuscript: Moses, Dorsey,
Critical revision of the manuscript for important
intellectual content: Moses, Dorsey, Matheson, Thier.
Statistical analysis: Moses.
Obtained funding: Moses, Matheson.
Administrative, technical, or material support:
Moses, Matheson, Thier.
Study supervision: Moses, Thier.
Financial Disclosures: Dr Moses is chairman
of The Alerion Institute and its associated Alerion Advisors, which conducts
studies for academic institutions, foundations, and industry on research policy.
He is also a member of the board of directors of Edison Pharmaceuticals. Dr
Moses is a Senior Advisor and Mr Matheson a Senior Vice President at The Boston
Consulting Group, which actively consults with academic medical centers, foundations,
and health companies, including pharmaceutical, biotechnology, and device
firms, in the United States, Europe, and Asia. Dr Thier is a member of the
Merck & Co Inc and Charles River Laboratories boards of directors. Dr
Dorsey is a strategic advisor to Avid Radiopharmaceuticals Inc.
Funding/Support: This study was supported by
The Alerion Institute and the Boston Consulting Group. Alerion and the Boston
Consulting Group provided a small stipend to Dr Dorsey while he was a resident
to conduct the research and analysis for the article. In addition, Boston
Consulting Group and Alerion provided in-kind support to compile the raw data
on device R&D and venture capital funding as well as access to subscription
databases and third-party information supplied by others.
Role of the Sponsor: Other than the involvement
of Dr Moses and Mr Matheson, the funding organizations had no role in the
design and conduct of the study; in the collection, management, analysis,
and interpretation of the data; or in the preparation, review, or approval
of the manuscript.
Acknowledgment: We thank John Craig, PhD, of
The Commonwealth Fund, Aaron Catlin, MS, of the Centers for Medicare &
Medicaid Services, and Andy Baldus, BS, of the National Institutes of Health
for their assistance.