We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Commentary |

Fostering Innovation and Discovery in Biomedical Research

Thomas R. Cech, PhD
JAMA. 2005;294(11):1390-1393. doi:10.1001/jama.294.11.1390.
Text Size: A A A
Published online


In today’s scientific era, molecular research has paved the way for the development of pharmaceuticals that are improving the lives of millions of patients. The discovery of the human immunodeficiency retrovirus as the causative agent of AIDS led to the development of reverse transcriptase inhibitors such as zidovudine. Monoclonal antibodies directed against tumor necrosis factor α have changed the lives of many patients with rheumatoid arthritis. Imatinib mesylate, a specific inhibitor of the bcr-abl protein kinase, has transformed the prognosis for patients with chronic myeloid leukemia; and as drug-resistant variants arise, DNA sequencing can identify the mutations responsible and provide a rational basis for further drug development.1,2 In 2004 the first angiogenesis inhibitors were approved by the US Food and Drug Administration, in one case for treatment of metastatic colorectal cancer and in another for age-related macular degeneration.3,4 There is reason for optimism that this is just the beginning, and that the huge investments in molecular biology and genomics research made 10 to 30 years ago will provide an increasingly robust flow of new and effective medicines.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview


Figure. Changes in US Biomedical Research Over the Past 25 Years
Graphic Jump Location

A, Source: Office of Extramural Research, National Institutes of Health. B, Fields included are anatomy; biochemistry; biology; biomedical engineering; biophysics; cell and molecular biology; genetics, microbiology, immunology, and virology; nutrition; pathology; pharmacology; physiology; zoology and other biosciences. Source: Survey of Graduate Students and Postdoctorates in Science and Engineering via WebCASPAR, National Science Foundation. C, Source: Survey of Graduate Students and Postdoctorates in Science and Engineering via WebCASPAR, National Science Foundation. B, C reproduced with permission.12



Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 15

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles