An international consensus for protecting the rights and interests of
research subjects has emerged in a process that began with the Declaration
of Helsinki1 and continues in the development
of official guidelines2 as well as a growing
scholarly literature.3 Despite this consensus,
legitimate ethical controversies persist. This article discusses points of
consensus and controversy in clinical research ethics, focusing on substantive,
rather than procedural, concerns.
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Web of Science® Times Cited: 39
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