Author Contributions: Dr King had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Fordis, King, Ballantyne, Greenberg, Schneider, Spann.
Acquisition of data: Fordis, King, Ballantyne, Jones, Greisinger.
Analysis and interpretation of data: Fordis, King, Schneider, Greisinger.
Drafting of the manuscript: Fordis, King.
Critical revision of the manuscript for important intellectual content: Fordis, King, Ballantyne, Jones, Schneider, Spann, Greenberg, Greisinger.
Statistical analysis: King.
Obtained funding: Fordis, Ballantyne, Schneider.
Administrative, technical, or material support: Fordis, Ballantyne, Schneider, Spann, Greisinger.
Study Supervision: Fordis, Greisinger.
Financial Disclosures: Drs King, Greenberg, Spann, and Greisinger and Ms Schneider have no financial relationships to disclose. Dr Fordis received grant support from AstraZeneca for the current study and has received grants from Merck and Merck/Schering-Plough. Dr Ballantyne has received grants and research support from AstraZeneca, diaDexus, Gene Logic, GlaxoSmithKline, Integrated Therapeutics, Kos, Merck, Novartis, Pfizer, Reliant, Sankyo Pharma, Schering-Plough, and Sanofi-Synthelabo; serves as a consultant for AstraZeneca, Bayer, Merck, Novartis, Pfizer, Reliant, Schering-Plough, and Sanofi-Synthelabo; and serves on the speakers’ bureau for AstraZeneca, Bristol-Meyers Squibb, Kos, Merck, Novartis, Pfizer, Reliant, Sanofi-Synthelabo, and Schering-Plough. Dr Jones has research support from Abbott, AstraZeneca, Kos, and Pfizer and serves as a consultant to AstraZeneca and Abbott.
Funding/Support: This study was supported by a grant from AstraZeneca Pharmaceuticals.
Role of the Sponsor: The study design was developed by the authors, and as part of the grant submission process, the study design was reviewed and approved for support by the funding organization. The funding organization had no role in the conduct of the study; in the collection, management, analysis, and interpretation of data; or in the preparation, review, or approval of the manuscript.
Acknowledgment: We wish to express appreciation to Baylor College of Medicine employees Quentin Smith, MS, for his assistance in manuscript preparation and editing and Brenda Galena for her assistance in data entry.