Author Contributions: Dr Chan had full access
to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Chan, Giovannucci,
Acquisition of data: Giovannucci, Meyerhardt,
Analysis and interpretation of data: Chan,
Giovannucci, Schernhammer, Fuchs.
Drafting of the manuscript: Chan, Giovannucci,
Critical revision of the manuscript for important
intellectual content: Chan, Giovannucci, Meyerhardt, Curhan, Fuchs.
Statistical analysis: Chan, Giovannucci, Schernhammer,
Obtained funding: Giovannucci, Fuchs.
Administrative, technical, or material support:
Study supervision: Fuchs.
Financial Disclosures: None reported.
Funding/Support: This study was supported by
grants CA 87969 and CA55075 from the National Cancer Institute, National Institutes
of Health. Dr Chan is a recipient of the American Gastroenterological Association/Foundation
for Digestive Health and Nutrition Research Scholar Award and career development
award CA107412 from the National Cancer Institute.
Role of the Sponsor: The National Cancer Institute,
the National Institutes of Health, the American Gastroenterological Association,
and the Foundation for Digestive Health and Nutrition had no role in the collection,
management, analysis, or interpretation of the data or the preparation, review,
or approval of the manuscript.
Acknowledgment: We acknowledge the continued
dedication of the participants in the Nurses’ Health Study. We also
acknowledge members of the Channing Laboratory at Brigham and Women’s
Hospital; in particular, Gideon Aweh, MS, Karen Corsano, MA, for their programming
assistance and Barbara Egan for her efforts in obtaining medical records.
Mr Aweh, Ms Corsano, and Ms Egan receive salary support from the National
Institutes of Health.