Author Contributions: Drs Ost, Tepper, Mihara,
Lander, and Heinzer had full access to all of the data in the study and take
responsibility for the integrity of the data and the accuracy of the data
Study concept and design: Ost, Tepper, Mihara,
Lander, Heinzer, Fein.
Acquisition of data; analysis and interpretation of
data; statistical analysis: Ost, Tepper, Mihara, Lander, Heinzer.
Drafting of the manuscript: Ost, Tepper, Mihara,
Critical revision of the manuscript for important
intellectual content: Ost, Tepper, Mihara, Lander.
Administrative, technical, or material support:
Study supervision: Ost, Fein.
Financial Disclosures: None reported.
Acknowledgment: We thank Sam Schulman, MD,
and Clive Kearon, MB, MRCP, FRCP, PhD, McMaster University, Hamilton, Ontario,
Florent Boutitie and Laurent Pinede, MD, PhD, Centre Hospitalier Universitaire
de Lyon, France, and A. G. Fennerty, MD, and Edward F. O’Sullivan, MD,
St Vincent’s Hospital, Melbourne, Australia, for reviewing and providing
data; Dr Schulman for providing additional follow-up data not available in
the initial published reports; and Michael Stoto, PhD, Harvard School of Public
Health, Boston, Mass, for critical review of an earlier version of the manuscript
and for technical advice.