Finding ways to prevent firearm injuries is a challenge for metropolitan areas throughout the United States. Gun violence historically has been a problem in cities, and youths have been affected disproportionately. A concerted effort has been under way during the past few decades to build the evidence base for youth violence prevention, and a number of effective strategies are now available for preventing behaviors that underlie firearm violence involving youths. These strategies include programs that (1) enhance youth skills and motivation to behave nonviolently and resolve conflicts peacefully, (2) promote positive relationships between youth and adults (e.g., parenting and mentoring programs), and (3) influence the social, environmental, and economic characteristics of schools, workplaces, and neighborhoods in ways that can reduce the likelihood of youth violence (e.g., encouraging social connectedness and facilitating economic opportunities).4† In addition, new approaches are being tried and tested, such as CeaseFire, which seeks to prevent street violence, particularly shootings, through outreach, conflict mediation, and the changing of community norms that support violence.5