Author Contributions: Drs St Clair, Sham, and
He had full access to all of the data in the study and take responsibility
for the integrity of the data and the accuracy of the data analysis. Drs St
Clair and Xu contributed equally to this work.
Study concept and design: St Clair, He.
Acquisition of data: Xu, Wang, Yu, Fang, Zhang,
Zheng, Gu, Feng.
Analysis and interpretation of data: St Clair,
Xu, Zhang, Gu, Sham.
Drafting of the manuscript: St Clair, Zhang.
Critical revision of the manuscript for important
intellectual content: Xu, Wang, Yu, Fang, Zheng, Gu, Feng, Sham, He.
Statistical analysis: Xu, Zhang, Sham.
Obtained funding: Gu, He.
Administrative, technical, or material support:
Xu, Wang, Yu, Fang, Zheng, Feng, He.
Study supervision: St Clair, Gu, He.
Financial Disclosures: None reported.
Funding/Support: This work was supported by
the national 973 and 863 programs, Shanghai Municipal Commission of Science
and Technology, US National Alliance for Research into Schizophrenia and Affective
Disorders (NARSAD), The UK Royal Society, and the Natural National Science
Foundation of China.
Role of the Sponsor: The Ministry of Science
and Technology participated in the project’s design and management,
the NARSAD helped in project management, the Shanghai Municipal Commission
for Science and Technology helped with project analysis, the UK Royal Society
supported exchange visits from the United Kingdom and China, and the Natural
Science Foundation of China helped with project conduct and paper handling.
Acknowledgment: We are very grateful and thank
Ezra Susser, MD, DrPh, of the Department of Epidemiology, Mailman School of
Public Health, Columbia University, for encouragement and helpful comments
in preparing the manuscript. Rick Lathe, PhD, Biomedical Sciences, University
of Edinburgh, Edinburgh, Scotland, also made helpful suggestions.