Advisory Board: David Bihari, MD; Christian
Brun-Buisson, MD; Timothy Evans, MD; John Heffner, MD; Norman Paradis, MD;
Adrienne Randolph, MD.
Author Contributions: Dr Curley had full access
to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Curley, Hibberd,
Wypij, Thompson, Matthay, Arnold.
Acquisition of data: Curley, Fineman, Grant,
Barr, Cvijanovich, Sorce, Luckett.
Analysis and interpretation of data: Curley,
Hibberd, Wypij, Shih, Thompson, Arnold.
Drafting of the manuscript: Curley, Hibberd,
Wypij, Shih, Matthay, Arnold.
Critical revision of the manuscript for important
intellectual content: Curley, Hibberd, Fineman, Wypij, Shih, Thompson,
Grant, Barr, Cvijanovich, Sorce, Luckett, Matthay, Arnold.
Statistical analysis: Curley, Hibberd, Wypij,
Obtained funding: Curley, Thompson, Hibberd,
Administrative, technical, or material support:
Curley, Fineman, Wypij, Grant, Barr, Cvijanovich, Sorce.
Study supervision: Curley.
Financial Disclosures: None reported.
Funding/Support: This study was supported by
grants RO1NR05336 from the National Institutes of Health/National Institute
of Nursing Research (NIH/NINR) and RR00064 and RR00054 from the NIH/National
Center for Research Resources (NCRR). Novametrix Medical Systems, Medical
Ventures, and i-STAT Corporation contributed equipment for this study.
Role of the Sponsor: The NIH/NINR, NIH/NCRR,
Novametrix Medical Systems, Medical Ventures, and i-STAT Corporation were
not involved in the design and conduct of the study; in the collection, management,
analysis, and interpretation of the data; or in the preparation, review, or
approval of the manuscript.
Participants in the Pediatric Prone Study Group:Children's Hospital Boston, Boston, Mass: J. H. Arnold,
R. Johnson, M. LaBrecque, J. E. Thompson; Children's Memorial
Hospital, Chicago, Ill: L. Sorce, D. Steinhorn; Primary Children's Medical Center, Salt Lake City, Utah: M. J. Chellis
Grant, C. Maloney; University of California, San Francisco: L. D. Fineman, J. Gutierrez, M. A. Matthay; Vanderbilt
Children's Hospital, Nashville, Tenn: F. E. Barr, J. Forlidas, A. Johnson; Children's Medical Center of Dallas, Dallas, Tex: P. M.
Luckett, S. Molitor-Kirsch; Children's Hospital Oakland,
Oakland, Calif: N. Cvijanovich, L. Wertz. Data Coordination
Center: P. L. Hibberd, P. Hopkins, M. McCarthy, A. Netson, M. C. Shih,
S. Wong, D. Wypij. Project Director: M. LaBrecque. External Quality Monitor: R. Lebet. Data and Safety Monitoring Board: K. Stone (chair), R. Clark, R. M.
Kacmarek, D. A. Schoenfeld.
Acknowledgment: We thank the pediatric critical
care nurses, respiratory therapists, physicians, and our patients and their
families who supported this clinical trial, and our colleagues in the Pediatric
Acute Lung Injury and Sepsis Investigators network who helped sustain this