0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Review | Clinician's Corner

Coffee Consumption and Risk of Type 2 Diabetes A Systematic Review

Rob M. van Dam, PhD; Frank B. Hu, MD, PhD
JAMA. 2005;294(1):97-104. doi:10.1001/jama.294.1.97.
Text Size: A A A
Published online

Context Emerging epidemiological evidence suggests that higher coffee consumption may reduce the risk of type 2 diabetes.

Objective To examine the association between habitual coffee consumption and risk of type 2 diabetes and related outcomes.

Data Sources and Study Selection We searched MEDLINE through January 2005 and examined the reference lists of the retrieved articles. Because this review focuses on studies of habitual coffee consumption and risk of type 2 diabetes, we excluded studies of type 1 diabetes, animal studies, and studies of short-term exposure to coffee or caffeine, leaving 15 epidemiological studies (cohort or cross-sectional).

Data Extraction Information on study design, participant characteristics, measurement of coffee consumption and outcomes, adjustment for potential confounders, and estimates of associations was abstracted independently by 2 investigators.

Data Synthesis We identified 9 cohort studies of coffee consumption and risk of type 2 diabetes, including 193 473 participants and 8394 incident cases of type 2 diabetes, and calculated summary relative risks (RRs) using a random-effects model. The RR of type 2 diabetes was 0.65 (95% confidence interval [CI], 0.54-0.78) for the highest (≥6 or ≥7 cups per day) and 0.72 (95% CI, 0.62-0.83) for the second highest (4-6 cups per day) category of coffee consumption compared with the lowest consumption category (0 or ≤2 cups per day). These associations did not differ substantially by sex, obesity, or region (United States and Europe). In the cross-sectional studies conducted in northern Europe, southern Europe, and Japan, higher coffee consumption was consistently associated with a lower prevalence of newly detected hyperglycemia, particularly postprandial hyperglycemia.

Conclusions This systematic review supports the hypothesis that habitual coffee consumption is associated with a substantially lower risk of type 2 diabetes. Longer-term intervention studies of coffee consumption and glucose metabolism are warranted to examine the mechanisms underlying the relationship between coffee consumption and type 2 diabetes.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Figures

Figure. Relative Risks for the Association Between Coffee Consumption for Individual Cohort Studies and All Cohort Studies Combined
Graphic Jump Location

Relative risks were incidence density ratios from proportional hazards models, except for the study by van Dam et al,30 which used odds ratios obtained by logistic regression analysis to estimate relative risks. CI indicates confidence interval. The size of the data markers (squares) corresponds to the weight of the study in the meta-analysis.

Tables

References

CME


You need to register in order to view this quiz.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

13,902 Views
302 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Abstracts from the First Annual Scholarly Day. Proc (Bayl Univ Med Cent) 2015;28(3):321-4.
Natural Products for the Treatment of Type 2 Diabetes Mellitus. Planta Med Published online Jul 1, 2015;
Jobs
JAMAevidence.com

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Quick Reference

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Quick Reference

×
brightcove.createExperiences();