Author Contributions: Dr Tleyjeh had full access
to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Tleyjeh, Steckelberg,
Acquisition of data: Tleyjeh, Steckelberg,
Murad, Anavekar, Ghomrawi, Mirzoyev, Moustafa.
Analysis and interpretation of data: Tleyjeh,
Steckelberg, Ghomrawi, Hoskin, Mandrekar, Wilson, Baddour.
Drafting of the manuscript: Tleyjeh, Steckelberg,
Mirzoyev, Hoskin, Mandrekar, Baddour.
Critical revision of the manuscript for important
intellectual content: Tleyjeh, Steckelberg, Murad, Anavekar, Ghomrawi,
Moustafa, Mandrekar, Wilson, Baddour.
Statistical analysis: Tleyjeh, Hoskin, Mandrekar.
Obtained funding: Baddour.
Administrative, technical, or material support:
Steckelberg, Ghomrawi, Mirzoyev, Baddour.
Study supervision: Tleyjeh, Steckelberg, Wilson,
Financial Disclosures: None reported.
Funding/Support: This study was supported in
part by grants AR30582 from the Public Health Service and HL59205 from the
National Institutes of Health.
Role of the Sponsor: The funding organizations
had no role in the design and conduct of the study; the collection, management,
analysis, and interpretation of the data; or the preparation, review, or approval
of the manuscript.
Previous Presentation: Presented in part as
an abstract at the American College of Cardiology Scientific Meeting; March
6-9, 2005; Orlando, Fla.
Acknowledgment: We thank Jennifer L. St. Sauver,
PhD, for her generous advice and review of the manuscript and Barbara Yawn,
MD, for her help with study coordination.