In a randomized controlled trial to assess the effect of orlistat vs
placebo, combined with diet, exercise, and behavioral therapy, in the treatment
of obese adolescents, Chanoine and colleaguesArticle found
that adolescents who received orlistat had a greater reduction in body mass
index compared with those receiving placebo at the 1-year study’s conclusion.
In an editorial, JoffeArticle discusses the need for
safe, comprehensive, and individualized treatment of adolescent obesity.