As with most infectious diseases, tuberculosis (TB) is not randomly
distributed; it thrives in specific groups and under specific conditions in
association with identified and unidentified factors that confer vulnerability
to the disease. Available information on the association between TB and the
many known conditions and circumstances that influence vulnerability to the
disease has been reviewed recently and is summarized in the Box.1,2 These
conditions and circumstances mainly include 3 broad categories of factors:
individual biological factors (eg, immunodeficiency states), social and economic
circumstances (eg, crowding, poverty, poor nutrition), and environmental and
institutional factors (eg, silica dust, poor ventilation).
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