Author Contributions: Dr Shear and Ms Houck
had full access to all of the data in the study and take responsibility for
the integrity of the data and the accuracy of the data analysis.
Study concept and design: Shear, Frank.
Acquisition of data: Shear, Frank.
Analysis and interpretation of data: Shear,
Frank, Houck, Reynolds.
Drafting of the manuscript: Shear, Houck.
Critical revision of the manuscript for important
intellectual content: Shear, Frank, Reynolds.
Statistical analysis: Shear, Frank, Houck,
Obtained funding: Shear.
Administrative, technical, or material support:
Study supervision: Shear, Frank.
Financial Disclosures: Dr Shear has received
financial support from Pfizer and Forest Pharmaceuticals. Dr Frank has received
financial support from Pfizer, Pfizer Italia, Eli Lilly, Forest Research Institute,
and the Pittsburgh Foundation.
Funding/Support: This work was supported by
grants R01MH60783, P30MH30915, and P30MH52247 from the National Institute
of Mental Health (NIMH).
Role of the Sponsor: The NIMH had no direct
input into the design or conduct of the study; collection, management, analysis,
or interpretation of the data; or preparation, review, or approval of the
Acknowledgment: We acknowledge the contributions
of the following individuals, without whose assistance this project would
not have been possible: Krissa Caroff, BS (study coordinator); Jacqueline
Fury, BS (study research associate); Russell Silowash, BS (data manger); Mary
Herschk (study administrative assistant); Rose Zingrone, LCSW, and Randi Taylor,
PhD (independent evaluators); Andrea Fagiolini, MD (study pharmacotherapist);
Bonnie Gorscak, PhD (CGT backup supervisor); Allan Zuckoff, PhD (study psychotherapist
and trainer in motivational enhancement therapy); Daniel Ford, MD, Wayne Katon,
MD, and Sidney Zisook, MD (data and safety monitoring board consultants);
and David J. Kupfer, MD, Edna Foa, PhD, Holly Prigerson, PhD, and Camille
Wortman, PhD (consultants).