Author Contributions: Drs Norris and Rewers (principal investigator) had full access to all of the
data in the study and take responsibility for the integrity of the data and
the accuracy of the data analysis.
Study concept and design: Norris, Hoffenberg,
Acquisition of data: Norris, Hoffenberg, Taki,
Miao, Haas, Emery, Erlich, Eisenbarth, Rewers.
Analysis and interpretation of data: Norris,
Barriga, Hoffenberg, Sokol, Erlich, Eisenbarth, Rewers.
Drafting of the manuscript: Norris, Hoffenberg.
Critical revision of the manuscript for important
intellectual content: Norris, Barriga, Taki, Miao, Haas, Emery, Sokol,
Erlich, Eisenbarth, Rewers.
Statistical analysis: Norris, Barriga.
Obtained funding: Norris, Eisenbarth, Rewers.
Administrative, technical, or material support:
Norris, Emery, Erlich, Rewers.
Study supervision: Norris, Taki, Rewers.
Protocol development: Norris, Erlich, Eisenbarth,
Clinical component development: Hoffenberg.
HLA genotyping: Erlich.
Measurement of autoantibodies: Miao, Eisenbarth.
Clinical evaluation of antibody-positive children: Hoffenberg, Haas, Sokol.
Database preparation and management: Barriga,
Study coordinator: Taki.
Financial Disclosures: None reported.
Funding/Support: This research was supported
by National Institutes of Health grants R01-DK32493, DK50979, DK32083, DK49654,
Autoimmune Prevention Center AI 50864, Diabetes Endocrine Research Center,
Clinical Investigation & Bioinformatics Core P30 DK 57516, and the General
Clinical Research Centers Program, National Center for Research Resources
Role of the Sponsors: The funding sources did
not participate in the design and conduct of the study; in the collection,
analysis, and interpretation of the data; or in the preparation, review, or
approval of the manuscript.
Acknowledgment: We would like to acknowledge
the dedicated and talented staff of the DAISY study for their clinical, data,
and laboratory support. We are indebted to all of the children and their families
who generously volunteered their time and knowledge.