In the late 1980s part of my routine, as the director of a pediatric
human immunodeficiency virus (HIV)/AIDS clinic, was to attend funerals of
my patients, children who succumbed to this disease. Now I am attending their
graduations from high school and some of my patients are going to college.
This anecdotal observation about the dramatic impact of highly active antiretroviral
treatment (HAART) on the outcome of HIV infection in children is substantiated
by the results reported by Berk and colleagues1 in
this issue of JAMA, which demonstrate that decreased
HIV progression and improved survival of infected children are associated
with early and more advanced antiretroviral therapy (ART).
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