Author Contributions: Dr Zink had full access
to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Zink, Tarwater, Clements,
Acquisition of data: Zink, Uhrlaub, DeWitt,
Voelker, Bullock, Mankowski, Tarwater, Barber.
Analysis and interpretation of data: Zink,
Mankowski, Tarwater, Clements, Barber.
Drafting of the manuscript: Zink, Uhrlaub,
DeWitt, Voelker, Bullock, Mankowski, Tarwater, Clements, Barber.
Critical revision of the manuscript for important
intellectual content: Zink, Clements, Barber.
Statistical analysis: Tarwater.
Obtained funding: Zink, Clements.
Administrative, technical, or material support:
Zink, Uhrlaub, DeWitt, Voelker, Bullock, Mankowski, Clements, Barber.
Study supervision: Zink, Barber.
Financial Disclosures: Drs Zink and Barber
are named as inventors on a patent pending for minocycline to treat HIV infection.
The patent will be held by the Johns Hopkins University. Otherwise no other
authors reported financial disclosures.
Funding/Support: These studies were supported
by grants MH069116 and NS44815 from the National Institutes of Health.
Role of the Sponsor: The National Institutes
of Health did not participate in the design and conduct of the study, in the
collection, analysis, and interpretation of the data, or in the preparation,
review, or approval of the manuscript.
Acknowledgment: We thank April Hargrove, John
Anderson, Lucio Gama, and Ming Li for technical assistance and Jessica Carman
for fruitful discussions.