Author Contributions: Dr Lindor had full access
to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Lindor, Rabe, Petersen,
Goldberg, de Andrade, Boardman.
Acquisition of data: Lindor, Rabe, Petersen,
Baron, Gallinger, Aronson, Hopper, Jass, LeMarchand, Grove, Potter, Newcomb,
Terdiman, Conrad, Moslein, Goldberg, Anton-Culver, Thibodeau, Boardman.
Analysis and interpretation of data: Lindor,
Rabe, Petersen, Haile, Casey, Baron, Bapat, Hopper, LeMarchand, Potter, Newcomb,
Goldberg, Ziogas, de Andrade, Siegmund, Seminara.
Drafting of the manuscript: Lindor, Rabe, Petersen,
Baron, Hopper, Moslein, Anton-Culver.
Critical revision of the manuscript for important
intellectual content: Lindor, Rabe, Petersen, Haile, Casey, Baron,
Gallinger, Bapat, Aronson, Hopper, Jass, LeMarchand, Grove, Potter, Newcomb,
Terdiman, Conrad, Moslein, Goldberg, Ziogas, de Andrade, Siegmund, Thibodeau,
Statistical analysis: Lindor, Rabe, Haile,
Ziogas, de Andrade, Siegmund.
Obtained funding: Lindor, Petersen, Gallinger,
Hopper, Jass, LeMarchand, Grove, Potter, Newcomb, Seminara.
Administrative, technical, or material support:
Lindor, Petersen, Casey, Hopper, Jass, Goldberg, Anton-Culver, Thibodeau,
Study supervision: Lindor, Petersen, Hopper,
Financial Disclosures: None reported.
Funding/Support: This work was supported by
the National Cancer Institute, National Institutes of Health, under RFA CA-95-011
and through cooperative agreements with the members of the Colon Cancer Family
Registry and principal investigators.
Role of the Sponsors: The National Cancer Institute
and the Colon Cancer Family Registry had no role in the design and conduct
of the study; in the collection, analysis, and interpretation of the data;
or in the preparation, review, or approval of the manuscript.
Disclaimer: The content of this article does
not necessarily reflect the views or policies of the National Cancer Institute
or any of the collaborating centers in the Cooperative Family Registries,
nor does mention of trade names, commercial products, or organizations imply
endorsement by the US government or the Cooperative Family Registry. Collaborating
centers include the Australian Colorectal Cancer Family Registry (UO1 CA097735),
the USC Familial Colorectal Neoplasia Collaborative Group (UO1 CA074799),
Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (UO1 CA074800),
Ontario Registry for Studies of Familial Colorectal Cancer (UO1 CA074783),
Seattle Colorectal Cancer Family Registry (UO1 CA074794), University of Hawaii
Colorectal Cancer Family Registry (UO1 CA074806), and University of California,
Irvine Informatics Center (UO1 CA078296).
Acknowledgment: We thank the many families
who have participated in research studies that facilitated this specific study.
We also thank the following individuals for their assistance in this study:
Kristin Lee, John Hake, Hema Vankayala, MD, Robert Vierkant, MAS, and Duncan