0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Clinical Crossroads Update |

A 60-Year-Old Woman Trying to Discontinue Hormone Replacement Therapy, 2 Years Later

Eileen E. Reynolds, MD
JAMA. 2005;293(14):1780. doi:10.1001/jama.293.14.1780.
Text Size: A A A
Published online

Extract

In a Clinical Crossroads article published April 24, 2002,1 Deborah Grady, MD, MPH, discussed the case of a 60-year-old woman with a family history of breast cancer and a personal history of surgical menopause at age 40 who had experienced severe hot flashes while trying to discontinue hormone therapy.

In her discussion, which was published after the Women’s Health Initiative announcement regarding concerning trends in the study2 but prior to publication of the study,3,4 Dr Grady discussed growing concerns about the potentially increased risk of breast cancer risk and coronary events in users of hormone therapy based on the Heart and Estrogen/Progestin Replacement Study, other published randomized trials, and early reports from the Women’s Health Initiative. She suggested that Mrs W try again to taper her estrogen, but over an extended period of time. Dr Grady also suggested that Mrs W consider trying a selective serotonin reuptake inhibitor to help with symptoms. However, she noted that estrogen remains the most effective therapy for relief of vasomotor symptoms of menopause and suggested that if Mrs W were unable to taper or discontinue the estrogen, that Mrs W could continue the estrogen, but for symptom relief rather than long-term prevention of disease.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
CME Related by Topic
PubMed Articles
Jobs
brightcove.createExperiences();