Author Contributions: Mr Peterson and Dr Siscovick had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Shlipak, Fried, Cushman,
Acquisition of data: Cushman, Peterson, Siscovick,
Analysis and interpretation of data: Shlipak,
Cushman, Manolio, Peterson, Stehman-Breen, Newman, Bleyer, Newman, Siscovick,
Drafting of the manuscript: Shlipak, Cushman,
Peterson, Stehman-Breen, Bleyer.
Critical revision of the manuscript for important
intellectual content: Shlipak, Fried, Cushman, Manolio, Peterson, Newman,
Bleyer, Newman, Siscovick, Psaty.
Statistical analysis: Shlipak, Peterson, Bleyer,
Obtained funding: Shlipak, Newman, Siscovick,
Administrative, technical, or material support:
Study supervision: Stehman-Breen, Newman, Siscovick.
Financial Disclosures: Dr Fried has received
honoraria from Pfizer and research support from Boehringer Ingelheim. Dr Stehman-Breen
is an employee of Amgen Inc. No other authors reported financial disclosures.
Funding Support: Drs Shlipak and Fried are
funded by grant R01 HL073208-01 from the National Heart, Lung, and Blood Institute.
Dr Shlipak is also supported by the American Federation for Aging Research
and National Institute on Aging (Paul Beeson Scholars Program) and the Robert
Wood Johnson Foundation (Generalist Faculty Scholars Program). Dr Fried is
supported by an Advanced Research Career Development Award from the Medical
Service of Veterans Affairs. The CHS Study is supported by contracts N01-HC-85079
through N01-HC-85086, N01-HC-35129, and N01 HC-15103 from the National Heart,
Lung, and Blood Institute.
Role of the Sponsor: This study was funded
through contracts with the National Heart, Lung, and Blood Institute (NHLBI)
and included substantial NHLBI involvement in data collection, analysis, and
interpretation and manuscript preparation.
Acknowledgment: A full list of participating
CHS investigators and institutions can be found at http://www.chs-nhlbi.org