Author Contributions: Dr Granger had full access
to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Mehta, Alexander,
Acquisition of data: Alexander, Armstrong,
Analysis and interpretation of data: Mehta,
Alexander, Van de Werf, Armstrong, Pieper, Garg, Granger.
Drafting of the manuscript: Mehta, Armstrong,
Critical revision of the manuscript for important
intellectual content: Mehta, Alexander, Van de Werf, Armstrong, Pieper,
Garg, Califf, Granger.
Statistical expertise: Mehta, Pieper, Garg,
Obtained funding: Armstrong, Granger.
Administrative, technical, or material support:
Alexander, Armstrong, Califf, Granger.
Study supervision: Van de Werf, Armstrong,
Financial Disclosures: Dr Alexander has received
research funding from Boehringer Ingelheim. Dr Van de Werf has served on the
speaker’s bureau and has received research grants from Boehringer Ingelheim
and Genentech Inc. Drs Armstrong and Granger have received research funding
from Boehringer Ingelheim and Genentech Inc. None of the other authors reported
Funding/Support: The ASSENT-2 trial was funded
by Boehringer Ingelheim and Genentech Inc, but the sponsors did not provide
specific funding for this analysis.
Role of the Sponsors: Boehringer Ingelheim
and Genentech Inc had no role in the design or conduct of the study, in the
collection, analysis, interpretation of the data, or in the preparation, review,
or approval of the manuscript.