Author Contributions: Dr Davis had full access
to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Wright, Cutler, Davis,
Cushman, Haywood, Papademetriou, Probstfield, Whelton.
Acquisition of data: Wright, Davis, Cushman,
Ford, Haywood, Leenen, Margolis, Papademetriou, Probstfield.
Analysis and interpretation of data: Wright,
Dunn, Cutler, Davis, Cushman, Ford, Haywood, Leenen, Margolis, Papademetriou,
Probstfield, Whelton, Habib.
Drafting of the manuscript: Wright, Dunn, Cutler,
Cushman, Ford, Haywood, Papademetriou, Probstfield.
Critical revision of the manuscript for important
intellectual content: Wright, Cutler, Davis, Cushman, Haywood, Leenen,
Margolis, Papademetriou, Probstfield, Whelton, Habib.
Statistical analysis: Dunn, Davis, Cushman,
Obtained funding: Wright, Cutler, Davis, Papademetriou,
Administrative, technical, or material support:
Wright, Cutler, Davis, Cushman, Leenen, Margolis, Probstfield.
Study supervision: Wright, Cutler, Davis, Cushman,
Leenen, Margolis, Papademetriou, Probstfield.
Financial Disclosures: Dr Wright has received
research grants, honoraria, and/or consulting fees from AstraZeneca, Aventis,
Bayer, Bristol-Myers Squibb, Eli Lilly & Co, Merck & Co, Novartis
Pharma AG, Pfizer Inc, Phoenix Pharmaceuticals, Searle & Co, SmithKline
Beecham, and Solvay/Unimed. Dr Davis has received consulting fees from Merck,
Pfizer, SmithKline Beecham/GlaxoWellcome, and Takeda. Dr Cushman has received
grants/research support and/or consulting fees/honoraria from Abbott, AstraZeneca,
Aventis, Biovail, Boehringer-Ingelheim, Bristol-Myers Squibb, Forest, King,
Kos, Novartis, Pfizer, Reddy, Sankyo, and Sanofi. Dr Whelton has received
honoraria from Pfizer. No other authors reported financial disclosures.
Funding/Support: This study was supported by
contract NO1-HC-35130 from the National Heart, Lung, and Blood Institute.
The ALLHAT investigators acknowledge contributions of study medications supplied
by Pfizer Inc (amlodipine), AstraZeneca (atenolol and lisinopril), and Bristol-Myers
Squibb (pravastatin) and financial support provided by Pfizer Inc.
Role of the Sponsors: The National Heart, Lung,
and Blood Institute sponsored the study and was involved in all aspects other
than direct operations of the study centers. This included collection, analysis,
and interpretation of the data plus the decision to submit the manuscript
for publication. Pfizer Inc, AstaZeneca, and Bristol-Myers Squibb had no role
in the design and conduct of the study; the collection, analysis, and interpretation
of the data; or the preparation or approval of the manuscript.
A list of the ALLHAT Collaborative Research Group members has been published previously.11