Author Contributions: Drs Garg, Adhikari, and
Rosas-Arellano had full access to all of the data in the study and take responsibility
for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Garg, Adhikari, Haynes.
Acquisition of data: Garg, Adhikari, McDonald,
Rosas-Arellano, Sam, Haynes.
Analysis and interpretation of data: Garg,
Adhikari, McDonald, Rosas-Arellano, Devereaux, Beyene, Sam, Haynes.
Drafting of the manuscript: Garg, Adhikari,
Critical revision of the manuscript for important
intellectual content: Garg, Adhikari, McDonald, Rosas-Arellano, Devereaux,
Beyene, Sam, Haynes.
Statistical analysis: Garg, Adhikari, Beyene.
Obtained funding: Garg, Haynes.
Administrative, technical, or material support:
Garg, Rosas-Arellano, Haynes.
Study supervision: Garg, Haynes.
Financial Disclosures: None reported.
Funding/Support: Dr Garg was supported by a
Canadian Institutes of Health Research (CIHR) Clinician Scientist Training
Award. Dr Devereaux was supported by a CIHR Senior Research Fellowship.
Role of the Sponsors: No funding source or
sponsor had any role in the design and conduct of the study; collection, management,
analysis, or interpretation of the data; or preparation, review, or approval
of the manuscript.
Acknowledgment: We acknowledge the work of
Linda Sheridan, who provided administrative help, and Tom Flemming, the librarian
who helped with the literature searches. We thank Dereck Hunt, MD, MSc, and
William Clark, MD, for their help and support.