The impact of adjuvant therapy for treatment of early stage breast cancer
has clearly reduced the risk of disease recurrence and breast cancer mortality.
The evolution of adjuvant therapy for treatment of early stage breast cancer
is a story of incrementalism, built on the solid observation made more 3 decades
ago that administration of postoperative chemotherapy improves outcome for
patients with breast cancer.1 Numerous large
randomized clinical trials have subsequently reaffirmed that early observation.2 With the characterization of the estrogen receptor
(ER) and the introduction of tamoxifen, adjuvant endocrine therapy proved
to be highly effective as another, although not mutually exclusive, systemic
approach for treatment of patients with tumors expressing ER. Additionally,
the benefit of tamoxifen conferred to patients with tumors expressing ER is
fairly similar across age groups.2 More recently,
the introduction of selective aromatase inhibitors as adjuvant endocrine therapy
in postmenopausal women appears to have incrementally improved outcome compared
with tamoxifen alone.3- 7
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 3
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Users' Guides to the Medical Literature
Table 9.2-2 Refuted Evidence From Studies of Physiologic or Surrogate Endpoints
The Rational Clinical Examination
Make the Diagnosis: Breast Cancer
All results at
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.