We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
This Week in JAMA |

This Week in JAMA FREE

JAMA. 2005;293(8):899. doi:10.1001/jama.293.8.899.
Text Size: A A A
Published online


Estrogen alone or in combination with progestin (E+P) has been prescribed to treat urinary incontinence in menopausal women, but there is little objective evidence of its efficacy. Hendrix and colleaguesArticle used data from the Women’s Health Initiative trials to assess the effects of estrogen alone or E+P on the 1-year incidence and severity of symptoms of stress, urge, and mixed incontinence in healthy postmenopausal women. They found that both hormone regimens increased the incidence of all types of incontinence and were associated with worsening of symptoms. In an editorial, DuBeauArticle discusses physiologic effects of estrogen on the urinary tract and its possible role in urinary incontinence.Article


Empirical treatment of acute cystitis in women is complicated by a high prevalence of antibiotic resistance among uropathogenic strains of Escherichia coli. Hooton and colleagues investigated the efficacy of a 3-day regimen of amoxicillin-clavulanate vs a 3-day regimen of ciprofloxacin in women with acute uncomplicated cystitis. They found that ciprofloxacin was superior to amoxicillin-clavulanate in achieving a clinical cure. At a 2-week follow-up, significantly more women who received ciprofloxacin had both microbiological cure and eradication of vaginal E coli.

See Article


Screening for depression is common in primary care settings, but little attention has been paid to assessing for a history of hypomania or mania suggestive of bipolar disorder. Das and colleagues screened for bipolar disorder in an urban adult primary care clinic and examined demographic, clinical, and treatment characteristics of patients with a positive screening test result. In this urban and largely poor patient population, the prevalence of having a positive screening for lifetime bipolar disorder was 9.8%, which was consistent across demographic variables. Bipolar disorder was often underrecognized and appropriate medication not prescribed.

See Article


The prevalence of 2 breast cancer susceptibility genes, BRCA1 and BRCA2, in invasive breast cancer is well described, but it is not known whether these mutations are associated with ductal carcinoma in situ (DCIS). Claus and colleagues used data from a case-control study of women with DCIS to estimate the prevalence of these mutations. They found disease-associated BRCA1 and BRCA2 mutations in 0.8% and 2.4% of DCIS cases, respectively, which is similar to the prevalence reported in invasive breast cancer.

See Article


Randomized clinical trials (RCTs) often compare an innovative or an experimental therapy with standard treatment. Soares and colleaguesArticle were interested in assessing the probability that the innovative treatment would be superior to the standard treatment, accounting for factors that can affect the outcome of RCTs. They reviewed 59 high-quality, phase 3 RCTs conducted by the Radiation Therapy Oncology Group from 1968 to 2002. They found no evidence that innovative are superior to standard treatments. In the studies reviewed, standard treatment was preferred to innovative treatment in 71% of the trials. Innovations offered no survival advantage and were somewhat more likely to result in treatment-related mortality. In an editorial, Grann and GrannArticle discuss the importance of clinical trials to ensure treatment is evidence-based.


Over a 74-year career, Michael E. DeBakey, MD, has published more than 1600 scientific articles, performed more than 60 000 surgeries, and conducted research that was key to important innovations in cardiovascular surgery. Many consider him to be the greatest surgeon ever.

See Article


Current options for reperfusion therapy, in particular, pharmacological facilitation of primary percutaneous coronary intervention (PCI), are reviewed by Gersh and colleagues.

See Article


Influenza cannot be confirmed or excluded based on clinical findings alone.

See Article


Translate clinical research findings “from page to patient” with JAMA’s new interactive teleconferences.

See Article


For your patients: Information about influenza.

See Article



Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...