Author Contributions: Dr Hendrix had full access
to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Hendrix, Nygaard,
Acquisition of data: Hendrix, Wallace, McNeeley.
Analysis and interpretation of data: Hendrix,
Cochrane, Nygaard, Handa, Barnabei, Iglesia, Aragaki, Naughton, Wallace.
Drafting of the manuscript: Hendrix, Cochrane,
Nygaard, Barnabei, Iglesia, Aragaki, Wallace.
Critical revision of the manuscript for important
intellectual content: Hendrix, Cochrane, Nygaard, Handa, Barnabei,
Iglesia, Aragaki, Naughton, Wallace, McNeeley.
Statistical analysis: Nygaard, Aragaki.
Obtained funding: Hendrix, Wallace.
Administrative, technical, or material support:
Hendrix, Cochrane, Naughton, McNeeley.
Study supervision: Hendrix, Barnabei.
Financial Disclosure: Dr Hendrix has received
research funding from Lilly. None of the other authors reported any disclosures.
Funding/Support: The National Heart, Lung,
and Blood Institute funds the Women’s Health Initiative program. Wyeth-Ayerst
provided the study pills (active and placebo).
Role of the Sponsor: The National Heart, Lung,
and Blood Institute participated in the design, conduct, and oversight of
the trial and reviewed this report. Wyeth-Ayerst provided study pills only
and had no involvement in the design or conduct of the trial.
Acknowledgment: The Women’s Health Initiative
(WHI) Steering Committee gratefully acknowledges the dedicated efforts of
the investigators and staff, who are listed at http://www.whi.org.
The WHI also recognizes the WHI participants for their extraordinary commitment
to the WHI program. We thank Andrea LaCroix, PhD, for her critical evaluation
and review of the manuscript.