Author Contributions: Drs Blom, Doggen, and
Rosendaal had full access to all of the data in the study and take responsibility
for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Blom, Doggen, Rosendaal.
Acquisition of data: Blom, Doggen.
Analysis and interpretation of data: Blom,
Doggen, Osanto, Rosendaal.
Drafting of the manuscript: Blom, Doggen, Rosendaal.
Critical revision of the manuscript for important
intellectual content: Blom, Doggen, Osanto, Rosendaal.
Statistical analysis: Blom, Doggen, Rosendaal.
Obtained funding: Rosendaal.
Administrative, technical, or material support:
Blom, Doggen, Rosendaal.
Study supervision: Doggen, Osanto, Rosendaal.
Financial Disclosure: None reported.
Funding/Support: This research was supported
by grants NHS 98.113 from the Netherlands Heart Foundation and RUL 99/1992
from the Dutch Cancer Foundation.
Role of the Sponsor: The Netherlands Heart
Foundation and the Dutch Cancer Foundation did not play a role in the design
and conduct of the study; collection, management, analysis, and interpretation
of the data; preparation, review, or approval of the manuscript.
Acknowledgment: We thank the directors of the
Anticoagulation Clinics of Amersfoort (Dr M. H. H. Kramer), Amsterdam (Dr
M. Remkes), Leiden (Dr F. J. M. van der Meer), The Hague (Dr E. van Meegen),
Rotterdam (Dr A. A. H. Kasbergen) and Utrecht (Dr J. de Vries-Goldschmeding),
who made the recruitment of patients possible. The interviewers Ms. J. C.
M. van den Berg, Ms. B. Berbee, Ms S. van der Leden, Ms M. Roosen, and Ms
E. C. Willems of Brilman also performed the blood draws. Ms I. de Jonge, Ms
R. Roelofsen, Ms M. Streevelaar, Ms L. M. J. Timmers, and Ms J. J. Schreijer
are thanked for their secretarial, administrative support, and data management.
Ms A. van Hylckama Vlieg and Ms MD L. W. Tick took part in every step of the
data collection. R. van Eck, J. van der Meijden, Ms P. J. Noordijk, and Ms
Th. Visser performed the laboratory measurements. Dr H. L. Vos supervised
the technical aspects of DNA analysis. We thank all individuals who participated
in the MEGA study.