Author Contributions: Drs O’Brien and
Gage had full access to their Markov model and the data they collected and
had access to summary data from the SPORTIF trials. Both authors take responsibility
for the integrity of the data and the accuracy of the data analysis.
Study concept and design: O’Brien, Gage.
Acquisition of data: O’Brien, Gage.
Analysis and interpretation of data: O’Brien,
Drafting of the manuscript: O’Brien,
Critical revision of the manuscript for important
intellectual content: O’Brien, Gage.
Statistical analysis: O’Brien, Gage.
Obtained funding: Gage.
Study supervision: Gage.
Financial Disclosures: None reported.
Funding/Support: This study was supported by
Agency for Healthcare Research and Quality grant R01 HS10133 and by the Aetna
Quality Care Research Fund.
Role of the Sponsors: The study’s sponsors
had no role in the design and conduct of the study, in the collection, analysis,
and interpretation of the data, and in the preparation, review, or approval
of the manuscript.
Acknowledgment: We thank Deepak Voora, MD,
and Paul Milligan, RPh, who critiqued an early version of the manuscript.