Vitamin K (“Koagulation”) antagonists have been the sole
oral anticoagulants available for 60 years, ever since Link1 identified
the components in spoiled sweet clover responsible for bleeding in cattle.
Originally developed as a rat poison, vitamin K antagonists such as warfarin
are used successfully for the prevention of venous and arterial thromboembolism
for a wide range of clinical indications, including atrial fibrillation (AF),
venous thromboembolism (VTE), coronary artery disease, some orthopedic procedures,
and congenital or acquired thrombophilia. Since both age and obesity increase
the risk of atrial fibrillation2 and VTE, the
need for anticoagulants is increasing.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 35
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.