Quiz Ref IDVitiligo is a relatively common, acquired pigmentary
disorder characterized by areas of depigmented skin resulting from loss of
epidermal melanocytes. The prevalence of this disease varies from 0.1% to
2% in various global populations. Onset may occur at any age, but the incidence
usually peaks in the second and third decades of life. Patterns of distribution
of the disease include the generalized, acral or acrofacial, localized, and
segmental types. The generalized distribution is the most common pattern and
is characterized by symmetrically distributed areas of depigmentation. Segmental
vitiligo is the least common pattern and occurs in a dermatomal or quasi-dermatomal
distribution, often following the distribution of the trigeminal nerve. The
course of the disease is unpredictable. Vitiliginous skin lesions may remain
stable or slowly progress for years. In some instances, however, patients
undergo rapid, complete depigmentation in 1 or 2 years.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Immunohistochemical staining for melanocytes using an alkaline phosphatase
detection kit and a 1:5 dilution of MEL-5 antibody after predigestion for
4 minutes with protease. A, vitiliginous skin; B, healthy skin with scattered
cells in the basal layer positive to MEL-5 antibody (red chromogen) (magnification ×20).
A, Patient with more than 20% cutaneous surface depigmentation at baseline.
B, The same patient with extensive areas of repigmentation after receiving
47 narrowband UV-B treatments.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 58
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.