Author Contributions: Dr Farrell had full access
to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Li, Kosorok, Farrell,
Acquisition of data: Farrell, Laxova, West,
Green, Collins, Rock, Splaingard.
Analysis and interpretation of data: Li, Kosorok,
Farrell, Laxova, Green.
Drafting of the manuscript: Li, Farrell, Laxova.
Critical revision of the manuscript for important
intellectual content: Li, Kosorok, Farrell, West, Green, Collins, Rock,
Statistical analysis: Li, Kosorok, Farrell,
Obtained funding: Farrell.
Administrative, technical, or material support:
Kosorok, Farrell, Laxova, West, Green, Rock, Splaingard.
Study supervision: Kosorok, Farrell, West,
Financial Disclosures: None reported.
Funding/Support: This work was supported by
National Institutes of Health grants DK 34108 and M01 RR03186 and Cystic Fibrosis
Foundation grant A001-5-01.
Role of the Sponsors: The funding organizations
had no role in the design and conduct of the study, in the collection, analysis,
and interpretation of the data, or in the preparation, review, or approval
of the manuscript.
Acknowledgment: We are especially grateful
to Marjorie A. Rosenberg, PhD, of the University of Wisconsin for providing
information on antibiotics and Joseph T. Barbieri, PhD, of the Medical College
of Wisconsin for critically reviewing an early version of the manuscript.
We thank student Kyle J. McCarty for reviewing all culture data. Finally,
we thank the other investigators who have participated in the Wisconsin Cystic
Fibrosis Neonatal Screening Project, and Jeffrey P. Davis, MD, of the University
of Wisconsin for advice on experimental design and interpretation of early