Author Contributions: Dr Fonarow had full access
to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Fonarow, Adams, Abraham,
Acquisition of data: Fonarow, Adams, Abraham,
Analysis and interpretation of data: Fonarow,
Adams, Abraham, Yancy, Boscardin.
Drafting of the manuscript: Fonarow.
Critical revision of the manuscript for important
intellectual content: Adams, Abraham, Yancy, Boscardin.
Statistical analysis: Boscardin.
Administrative, technical, or material support:
Study supervision: Fonarow, Adams, Abraham,
Financial Disclosures: Drs Fonarow, Adams,
Abraham, and Yancy have received research grant funding and honoraria and
have served as consultants for Scios Inc. Dr Boscardin reported no financial
ADHERE Scientific Advisory Committee: William
T. Abraham, MD, Division of Cardiology, Ohio State University Medical Center,
Columbus; Kirkwood F. Adams, Jr, MD, Division of Cardiology, University of
North Carolina, Chapel Hill; Robert L. Berkowitz, MD, Heart Failure Program,
Hackensack University Hospital, Hackensack, NJ; Maria Rosa Costanzo, MD, Midwest
Heart Specialists, Edward Hospital, Naperville, Ill; Teresa DeMarco, MD, Division
of Cardiology, University of California, San Francisco; Charles L. Emerman,
MD, Department of Emergency Medicine, Cleveland Clinic Foundation and MetroHealth,
Cleveland, Ohio; Gregg C. Fonarow, MD, Ahmanson–UCLA Cardiomyopathy
Center, University of California, Los Angeles; Marie Galvao, CANP, Congestive
Heart Failure Program, Montefiore Medical Center, Bronx, NY; J. Thomas Heywood,
MD, Cardiomyopathy Program, Adult Cardiac Transplant, Loma Linda University
Medical Center, Loma Linda, Calif; Thierry H. LeJemtel, MD, Cardiology Division,
Albert Einstein Hospital, Bronx, NY; Lynne Warner Stevenson, MD, Cardiovascular
Division, Brigham and Women’s Hospital, Boston, Mass; Clyde W. Yancy,
MD, University of Texas Southwestern Medical Center, Cardiovascular Division,
St Paul University Hospital, Dallas.
ADHERE Study Group: Departments of Biostatistics
(Yu Ping Li, Janet Wynne, Mei Cheng, David Arnold) and Clinical Registries
(Jeannie M. Fiber), Scios Inc, Fremont, Calif.
The list of hospitals participating in the ADHERE Registry can be found
Funding/Support: The ADHERE registry and this
study were funded by Scios Inc.
Role of Sponsor: The sponsor used a committee
of academic advisors who were intimately involved in the design, conduct,
and interpretation of the ADHERE registry and this analysis of registry data.
The sponsor provided financial and material support for the registry and performed
the classification and regression tree analyses for this study based on the
input of the advisory committee. Dr Boscardin, who has no financial relationship
with the sponsor, recalculated and confirmed the classification and regression
tree analyses and also performed the logistic regression analyses. All of
the authors participated in the interpretation of the data and, along with
Dr Fonarow, had complete control over the contents of the manuscript and the
decision to submit the manuscript for publication.