Author Contributions: Drs Sink, Holden, and
Yaffe had full access to all of the data in the study and take responsibility
for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Sink, Yaffe.
Acquisition of data: Sink, Holden.
Analysis and interpretation of data: Sink,
Drafting of the manuscript: Sink, Holden.
Critical revision of the manuscript for important
intellectual content: Sink, Yaffe.
Obtained funding: Sink, Yaffe.
Administrative, technical, or material support:
Study supervision: Yaffe.
Financial Disclosure: Dr Yaffe has received
grant support through University of California, San Francisco from Pfizer
and Eli Lilly, and has served as a consultant for Novartis. Drs Sink and Holden
reported no financial disclosures.
Funding/Support: This work was supported in
part by a National Institute on Aging T32 training grant at the University
of California, San Francisco, and the Roena B. Kulynych Research Center, Wake
Forest University, Winston-Salem, NC (Dr Sink); and by the Paul Beeson Faculty
Scholars in Aging Research and grant NIA-R01 AG021918-01 (Dr Yaffe).
Role of the Sponsors: The sponsors had no role
in the design or conduct of the study, the data collection, interpretation
of results, or preparation and approval of the manuscript.
Acknowledgment: We thank Jay Luxenberg, MD,
for his thoughtful review of the manuscript.