Author Contributions: Dr Ponsonby had full
access to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Ponsonby, van der
Mei, Dwyer, Simmons, Kilpatrick.
Acquisition of data: Ponsonby, van der Mei,
Dwyer, Taylor, Simmons.
Analysis and interpretation of data: Ponsonby,
van der Mei, Dwyer, Blizzard, Taylor, Kemp, Kilpatrick.
Drafting of the manuscript: Ponsonby, van der
Mei, Dwyer, Kemp.
Critical revision of the manuscript for important
intellectual content: Ponsonby, van der Mei, Dwyer, Blizzard, Taylor,
Kemp, Simmons, Kilpatrick.
Statistical analysis: Ponsonby, van der Mei,
Dwyer, Blizzard, Kemp.
Obtained funding: Ponsonby, van der Mei, Dwyer,
Administrative, technical, or material support:
van der Mei, Simmons, Kilpatrick.
Funding/Support: This project was supported
with funding from the National Health and Medical Research Council of Australia,
the Australian Rotary Health Research Fund, and MS Australia. Dr van der Mei
was supported by the Cooperative Research Centre for Discovery of Genes for
Common Human Diseases (gene-CRC), and Dr Kilpatrick was a Viertel fellow.
The gene-CRC was established and is supported by the Australian government’s
Cooperative Research Centre’s programme. Serological assays were funded
by the Canberra Hospital Private Practice Fund.
Role of the Sponsors: No sponsors were involved
in the design of the study. The National Health and Medical Research Council
of Australia, the Australian Rotary Health Research Fund, and MS Australia
provided funds to support the funding of the study, including data collection,
management, analysis, and interpretation of the data. No sponsors were involved
in the preparation, review, or approval of the manuscript.
Acknowledgment: We thank the participants and
Trish Groom and Jane Pittaway for conducting the interviews; Natasha Newton
for administrative support and data entry; Sue Sawbridge and Tim Albion for
the development and management of the database; the Tasmanian Multiple Sclerosis
Society for assisting with the recruitment of volunteers; and Helmut Butzkueven,
FRACP, Andrew Hughes, FRACP, Bosidar Drulovis, MD, and Stan Sjieka, FRACP,
who were involved with the clinical diagnosis. We also thank David Hosmer,
PhD, for statistical advice with regard to composite EBV antibody modeling.