Author Contributions: Dr Willson had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Willson, Markovitz,
Bauman, Jacobs, Jefferson, Conaway, Egan.
Acquisition of data: Willson, Thomas, Markovitz,
DiCarlo, Pon, Jacobs, Jefferson.
Analysis and interpretation of data: Willson,
Thomas, Markovitz, DiCarlo, Jacobs, Jefferson, Conaway, Egan.
Drafting of the manuscript: Willson, Thomas,
Critical revision of the manuscript for important
intellectual content: Willson, Thomas, Markovitz, Bauman, DiCarlo,
Pon, Jacobs, Jefferson, Conaway, Egan.
Statistical analysis: Willson, Markovitz, Conaway,
Obtained funding: Willson, Egan.
Administrative, technical, or material support:
Willson, Thomas, Bauman, DiCarlo, Pon, Jacobs, Jefferson.
Study supervision: Willson, Thomas, Bauman,
Participating Centers and Primary Investigators: Arnold
Palmer Hospital for Children and Women (Lawrence D. Spack); Babies and Children’s
Hospital of New York (Peter M. Trinkaus); Brody School of Medicine, East Carolina
University (William E. Novotny); Children’s Hospital of Philadelphia
(Rodolfo I. Godinez); Children’s Medical Center of the University of
Virginia (Douglas F. Willson); Children’s Memorial Hospital (David M.
Steinhorn); Cincinnati Children’s Hospital Medical Center (Brian R.
Jacobs); Connecticut Children’s Medical Center (Aaron Zucker); Healthcare
of Atlanta at Egelston/Emory University School of Medicine (C. Robert Chambliss);
Inova Fairfax Hospital for Children (W. Keith Dockery); Kosair Children’s
Hospital (Vicki L. Montgomery); Medical University of South Carolina Children’s
Hospital (Joel B. Cochran); Penn State Children’s Hospital (Neal J.
Thomas); St Louis Children’s Hospital (Barry P. Markovitz); Shands Children’s
Hospital at the University of Florida (Ronald C. Sanders); Stanford University
School of Medicine (Joseph V. DiCarlo); Texas Children’s Hospital (Lawrence
S. Jefferson); University of Kentucky Children’s Hospital (Heinrich
A. Werner); University of Miami/Jackson Children’s Hospital (Gwenn McLaughlin);
Wake Forest University Baptist Medical Center (Loren A. Bauman); Weill Medical
College of Cornell University (Steven Pon).
Funding/Support: Funding for this study was
provided by an unrestricted grant from ONY Inc (Amherst, NY) to the University
of Virginia and to participating institutions on a per enrolled patient basis.
The funding was contractually committed prior to the start of the trial. ONY
Inc supplied surfactant for this study.
Role of the Sponsor: The study was conceived
by and the data were collected and analyzed by the authors. ONY Inc received
a copy of the complete database after the manuscript was accepted for publication
Acknowledgment: We acknowledge the technical
assistance of Susan Poppenberg, RN, Diane Willson, RN, MSN, and Margaret Ball,
RN. We also thank John Kattwinkel, MD, Arno Zaritsky, MD, and Adrienne Randolph,
MD, for their critical review of the manuscript.