Author Contributions: Ms Rodabough had full
access to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Cirillo, Wallace.
Acquisition of data: Wallace, Greenland, LaCroix,
Analysis and interpretation of data: Cirillo,
Wallace, Rodabough, Greenland, LaCroix, Limacher, Larson.
Drafting of the manuscript: Cirillo, Wallace,
Critical revision of the manuscript for important
intellectual content: Cirillo, Rodabough, Greenland, LaCroix, Limacher,
Statistical analysis: Cirillo, Rodabough, Larson.
Obtained funding: Wallace, Greenland.
Administrative, technical, or material support:
Wallace, Greenland, Limacher.
Study supervision: Wallace, LaCroix, Limacher.
Funding/Support: This study was funded by the
National Heart, Lung, and Blood Institute. The active study drug and placebo
were supplied by Wyeth-Ayerst Research Laboratories, Philadelphia, Pa.
Role of the Sponsor: Wyeth Pharmaceuticals
and the National Heart, Lung, and Blood Institute did not participate in the
design and conduct of the study, in the collection, analysis, and interpretation
of the data, or in the preparation, review, or approval of the manuscript.
Program Office (National Heart, Lung, and Blood Institute, Bethesda,
Md): Barbara Alving, Jacques E. Rossouw, Linda Pottern.
Clinical Coordinating Centers: (Fred Hutchinson
Cancer Research Center, Seattle, Wash) Ross L. Prentice, Garnet L. Anderson,
Andrea Z. LaCroix, Ruth E. Patterson, Anne McTiernan; (Wake Forest University
School of Medicine, Winston-Salem, NC) Sally Shumaker, Pentti Rautaharju;
(Medical Research Labs, Highland Heights, Ky) Evan Stein; (University of California
at San Francisco) Steven Cummings; (University of Minnesota, Minneapolis)
John Himes; (University of Washington, Seattle) Bruce Psaty.
WHI Clinical Centers: (Albert Einstein College
of Medicine, Bronx, NY) Sylvia Wassertheil-Smoller; (Baylor College of Medicine,
Houston, Tex) Jennifer Hays; (Brigham and Women's Hospital, Harvard Medical
School, Boston, Mass) JoAnn Manson; (Brown University, Providence, RI) Annlouise
R. Assaf; (Emory University, Atlanta, Ga) Lawrence Phillips; (Fred Hutchinson
Cancer Research Center, Seattle, Wash) Shirley A. Beresford; (George Washington
University Medical Center, Washington, DC) Judith Hsia; (Harbor-UCLA Research
and Education Institute, Torrance, Calif) Rowan Chlebowski; (Kaiser Permanente
Center for Health Research, Portland, Ore) Cheryl Ritenbaugh; (Kaiser Permanente
Division of Research, Oakland, Calif) Bette Caan; (Medical College of Wisconsin,
Milwaukee) Jane Morley Kotchen; (MedStar Research Institute/Howard University,
Washington, DC) Barbara V. Howard; (Northwestern University, Chicago, Ill)
Linda Van Horn; (Rush-Presbyterian-St Luke's Medical Center, Chicago,
Ill) Henry Black; (Stanford Center for Research in Disease Prevention, Stanford
University, Stanford, Calif) Marcia L. Stefanick; (State University of New
York at Stony Brook) Dorothy Lane; (The Ohio State University, Columbus) Rebecca
Jackson; (University of Alabama at Birmingham) Cora Beth Lewis; (University
of Arizona, Tucson/Phoenix) Tamsen Bassford; (University at Buffalo, Buffalo,
NY) Jean Wactawski-Wende; (University of California at Davis, Sacramento)
John Robbins; (University of California at Irvine, Orange) Allan Hubbell;
(University of California at Los Angeles) Howard Judd; (University of California
at San Diego, LaJolla/Chula Vista) Robert D. Langer; (University of Cincinnati,
Cincinnati, Ohio) Margery Gass; (University of Florida, Gainesville/Jacksonville)
Marian Limacher; (University of Hawaii, Honolulu) David Curb; (University
of Iowa, Iowa City/Davenport) Robert Wallace; (University of Massachusetts/Fallon
Clinic, Worcester) Judith Ockene; (University of Medicine and Dentistry of
New Jersey, Newark) Norman Lasser; (University of Miami, Miami, Fla) Mary
Jo O’Sullivan; (University of Minnesota, Minneapolis) Karen L. Margolis;
(University of Nevada, Reno) Robert Brunner; (University of North Carolina,
Chapel Hill) Gerardo Heiss; (University of Pittsburgh, Pittsburgh, Pa) Lewis
Kuller; (University of Tennessee, Memphis) Karen C. Johnson; (University of
Texas Health Science Center, San Antonio) Robert Brzyski; (University of Wisconsin,
Madison) Gloria Sarto; (Wake Forest University School of Medicine, Winston-Salem,
NC) Denise Bonds; (Wayne State University School of Medicine/Hutzel Hospital,
Detroit, Mich) Susan Hendrix.