Author Contributions: Dr Wong had full access
to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analyses.
Study concept and design: Wong, Hubbard.
Acquisition of data: Rosamond, Couper, Hubbard,
Analysis and interpretation of data: Wong,
Rosamond, Chang, Couper, Sharrett, Hubbard.
Drafting of the manuscript: Wong.
Critical revision of the manuscript for important
intellectual content: Wong, Rosamond, Chang, Couper, Sharrett, Hubbard,
Statistical analysis: Wong, Rosamond, Couper.
Obtained funding: Hubbard.
Administrative, technical, or material support:
Rosamond, Hubbard, Klein.
Study supervision: Hubbard.
Funding/Support: This study was supported by
contracts N01-HC-35125, N01-HC-35126, N01-HC-55015, N01-HC-55016, N01-HC-55018,
N01-HC-55019, N01-HC-55020, N01-HC-55021, and N01-HC-55022 from the National
Heart, Lung, and Blood Institute. Additional support was provided by the Sylvia
and Charles Viertel Clinical Investigator Award and the Biomedical Research
Council Singapore (Dr Wong).
Role of the Sponsors: The organizations funding
this study had no role in the design and conduct of this study; the analysis
and interpretation of data; or the preparation, review, or approval of the
Acknowledgment: We thank the staff and participants
in the ARIC study for their important contributions.