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A, Lumbar vertebra showing a deep smooth-walled erosion at the posterior
aspect. B, Fused lumbar vertebrae L2 and L3 showing focal diagenetic fossilization
and significant general demineralization. Arrowheads indicate level of fusion.
C, Osteopenic, granular appearance of the skull vault with loss of distinct
trabecular detail. This “salt and pepper skull” represents trabecular
resorption within medullary bone.
A, Photomicrograph of a histological section of the vertebral specimen
showing the typical “cookie-bite” tunneling osteoclasia of the
vertebral trabeculae (asterisks) (unstained, original magnification ×400).
B, For comparison, a bone tissue section of a recent case of hyperparathyroidism
reveals very similar defects at the trabecular surface (asterisks) (hematoxylin-eosin,
original magnification ×400).
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