Author Contributions: Drs Jonsson and Stefansson
had full access to all of the data in the study and take responsibility for
the integrity of the data and the accuracy of the data analysis.
Study concept and design: S. Jonsson, Thorsteinsdottir,
Kristjansson, Arnason, Hallgrimsson, Gulcher, Amundadottir, Stefansson.
Acquisition of data: S. Jonsson, Isaksson.
Analysis and interpretation of data: S. Jonsson,
Thorsteinsdottir, H. Jonsson, Kong, Gudbjartsson.
Drafting of the manuscript: S. Jonsson, Thorsteinsdottir.
Critical revision of the manuscript for important
intellectual content: S. Jonsson, Thorsteinsdottir, H. Jonsson, Kong,
Gudbjartsson, Kristjansson, Arnason, Isaksson, Hallgrimsson, Gulcher, Amundadottir,
Statistical analysis: H. Jonsson, Kong, Gudbjartsson.
Obtained funding: Stefansson.
Administrative, technical, or material support:
S. Jonsson, Thorsteinsdottir, Kristjansson, Arnason, Isaksson, Gulcher, Amundadottir,
Study supervision: S. Jonsson, Thorsteinsdottir.
Funding/Support: All of the work, data generation,
and analysis of this study was supported by deCODE Genetics.
Role of the Sponsor: deCODE Genetics participated
in the design and conduct of the study, the collection, analysis, and interpretation
of the data, and the preparation, review, and approval of the manuscript.
Independent Statistical Analysis: Kristjan
Jonasson, PhD, Associate Professor, Department of Mathematics, Faculty of
Science, University of Iceland, was given access to the complete data, including
genealogical data and lung cancer and smoking data, after coding of personal
identification numbers. Dr Jonasson completed a thorough check of the methods
and data analysis, and confirmed that the results reported in the submitted
manuscript are both statistically correct and in accordance with the data.
Acknowledgment: We thank the Icelandic Cancer
Registry for providing us with the list of patients with lung carcinoma.