Author Contributions: Dr C.-J. Chen had full
access to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: C.-L. Chen, Chiou,
Hsueh, C.-J. Chen.
Acquisition of data: C.-L. Chen, Hsu, Hsueh,
S.-Y. Chen, Wu, C.-J. Chen.
Analysis and interpretation of data: C.-L.
Chen, S.-Y. Chen, Wu, C.-J. Chen.
Drafting of the manuscript: C.-L. Chen.
Critical revision of the manuscript for important
intellectual content: C.-L. Chen, Hsu, Chiou, Hsueh, S..-Y. Chen, Wu,
Statistical analysis: C.-L. Chen, Hsu, S.-Y.
Obtained funding: C.-J. Chen.
Administrative, technical, or material support:
Chiou, Hsueh, C.-J. Chen.
Study supervision: Hsueh, C.-J. Chen.
The Blackfoot Disease Study Group: Graduate
Institute of Epidemiology, College of Public Health (Chien-Jen Chen, ScD,
Chi-Ling Chen, PhD, Lin-I Hsu, PhD, Wei-Liang Shih, MS, Yi-Hsiang Hsu, MS,
Chia-Yen Chen, BS, Yu-Chin Cheng, BS, and Li-Hua Wang, BS) and Graduate Institute
of Medical Technology, College of Medicine (Cheng-Yeh Lee, MS), National Taiwan
University, Taipei; School of Public Health, Taipei Medical University, Taipei,
Taiwan (Hung-Yi Chiou, PhD, Yu-Mei Hsueh, PhD, Meei-Maan Wu, PhD, Iuan-Horng
Wang, MS, Yu-Chun Lin, MS); Division of Biostatistics and Bioinformatics,
National Health Research Institute, Taipei, Taiwan (Shu-Yuan Chen, PhD); Division
of Environmental Health and Occupational Medicine, National Health Research
Institute, Kaohsiung, Taiwan (Wei-Lin Chou, MS); Department of Cardiology,
Cardinal Tien Hospital, Fu-Jen Catholic University, Taipei, Taiwan (Chih-Hao
Wang, MD, PhD); Department of Dermatology, National Taiwan University Hospital,
Taipei (Mei-Ping Tseng, MS).
Funding/Support: This study was supported by
grants NSC 83-0412-B002-231, NSC 91-2320-B002-075, NSC 92-2320-B002-136, and
NSC 92-2320-B002-135 from the National Science Council and DOH85-HR-503PL
from Department of Health, Executive Yuan, Taiwan.
Role of the Sponsors: The National Science
Council and Department of Health, Executive Yuan, Taiwan, were not involved
in the design and conduct of the study, in the collection, management, analysis,
and interpretation of the data, or in the preparation, review, or approval
of the manuscript.