Author Contributions: Dr Davis had full access
to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Davis, Kopecky, Hamilton,
Acquisition of data: Davis, Kopecky, Hamilton,
Griep, Saporito, Adams-Myers, Gross, Treece, Brewer, Tuttle.
Analysis and interpretation of data: Davis,
Kopecky, Hamilton, Onstad, Saporito, Garbe.
Drafting of the manuscript: Davis, Kopecky,
Hamilton, Griep, Adams-Myers.
Critical revision of the manuscript for important
intellectual content: Davis, Kopecky, Hamilton, Onstad, Saporito, Gross,
Treece, Brewer, Tuttle, Garbe.
Statistical analysis: Kopecky, Onstad.
Obtained funding: Davis, Adams-Myers, Garbe.
Administrative, technical, or material support:
Davis, Hamilton, Griep, Saporito, Adams-Myers, Gross, Treece, Brewer, Garbe.
Study supervision: Davis, Hamilton, Adams-Myers.
The Hanford Thyroid Disease Study Team: Fred
Hutchinson Cancer Research Center: Robert Griep, MD, Mark Saporito, MA, Peggy
Adams Myers, Ken Gross, MD, Gary Treece, MD, Gayle Brewer, MD, R. Michael
Tuttle, MD; Centers for Disease Control and Prevention, National Center for
Environmental Health, Division of Environmental Hazards and Health Effects:
Paul Garbe, DVM.
Funding/Support and Role of the Sponsor: The
Centers for Disease Control and Prevention (CDC) provided funding for the
Hanford Thyroid Disease Study through a contract to the the Fred Hutchinson
Cancer Research Center. A member of the administrative staff of the Centers
for Disease Control and Prevention Radiation Studies Branch served as project
officer for the contract and a member of the scientific staff served as scientific
advisor. Investigators and staff of the Fred Hutchinson Cancer Research Center
were responsible for all aspects of data collection and data analysis. The
authors were solely responsible for manuscript preparation and authorization
Acknowledgment: Many individuals and institutions
have contributed to the success of the HTDS. We especially thank the following
FHCRC staff for their valuable contributions in the following areas: administrative
support: Sandy Walbrek, Teri Kopp, Cathy Voigt, Janice Findley, Iona McKenzie,
Georgia Green, Berta Nicole-Blades, Christy Callahan; travel: Theresa Taggart;
tracing and recruiting: Beth King, Kathleen Koons, Allan Jaeger, Elizabeth
Acorda, Judith Dietert, Karen Queen, Richard Alvin Young, Jana Froese, Caroline
Tuman; CATI: Esther Kohler, Bruce Cummins, Shannon Greer; clinics: Thula Weisel,
Laurie Shields, Carl Steven Minor, Esther Ricardo-Bulis, Mari Hooten Lee,
Sally Kirk, Holly Roberts; thyroid ultrasound: Theresa Stanfel Hull, David
Sherman, Carmen Fletcher; medical records: Susan DeNeef, Sherry Shanabarger;
data operations: Surena Khatir, Bernard Moore, Elizabeth Carosso, Jan Kikuchi,
Elizabeth Noonan, Chuck Wiggins, Catherine Kirkwood, Len Gallardo, Linda Joos
(in memoriam); and statistical analysis: Dana K. Mirick. Bruce Kulander, MD,
reviewed all FNA slides. Bruce Napier, PhD, was especially helpful in developing
the dosimetry interview and in matters related to the implementation of the
computer system for estimating individual thyroid doses. We thank James Smith,
PhD, at the CDC for his helpful support throughout the project; and Patrick
Wall at the CDC for technical assistance in using the CIDER model. We extend
a special acknowledgment to all study participants and CATI respondents for
giving their time and personal information to make this study possible.