Author Contributions: Dr Benjamin had full
access to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analyses. Drs Vasan and Benjamin
contibuted equally to this article.
Study concept and design: Wang, D’Agostino,
Wolf, Vasan, Benjamin.
Acquisition of data: Wang, Levy, D’Agostino,
Analysis and interpretation of data: Wang,
Parise, Levy, D’Agostino, Vasan, Benjamin.
Drafting of the manuscript: Wang, Parise, D’Agostino,
Critical revision of the manuscript for important
intellectual content: Parise, Levy, D’Agostino, Wolf, Vasan,
Statistical analysis: Parise, D’Agostino.
Obtained funding: Wolf, Benjamin.
Administrative, technical, or material support:
Study supervision: Vasan, Benjamin.
Funding/Support: This work was supported by
National Institutes of Health/National Heart, Lung, and Blood Institute (NHLBI)
grants NO1-HC-25195, 6R01-NS-17950, and K23-HL074077-01 (Dr Wang) and K24-HL-04334
Role of the Sponsor: The NHLBI had no role
in the study design, analyses, or drafting of the manuscript. The NHLBI reviews
all manuscripts submitted for publication but it was not involved in the decision