Author Contributions: Dr Fox had full access
to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Fox, Sorlie, Savage.
Acquisition of data: Levy, D’Agostino,
Analysis and interpretation of data: Fox, Coady,
Sorlie, Meigs, D’Agostino, Wilson, Savage.
Drafting of the manuscript: Fox.
Critical revision of the manuscript for important
intellectual content: Coady, Sorlie, Levy, Meigs, D’Agostino,
Statistical analysis: Fox, Coady, Sorlie, D’Agostino,
Obtained funding: Levy.
Administrative, technical, or material support:
Meigs, D’Agostino, Savage.
Study supervision: Levy, Meigs, Wilson.
Funding/Support: This work was supported by
the National Heart, Lung, and Blood Institute’s Framingham Heart Study
(N01-HC-25195). Dr Meigs is supported by an American Diabetes Association
Career Development Award.
Role of the Sponsor: Drs Fox, Sorlie, and Savage
and Mr Coady, as employees of the National Heart, Lung, and Blood Institute,
contributed to the design and conduct of the study, the collection, analysis,
and interpretation of the data, and the preparation, review, and approval
of the manuscript.