Author Contributions: Dr Spagnoli had full
access to all of the data in the study and takes responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Spagnoli, Mauriello,Sangiorgi,
Fratoni, Bonanno, Schwartz, Pistolese,Ippoliti, Holmes.
Acquisition of data: Mauriello, Fratoni, Piepgras,Pistolese,
Analysis and interpretation of data: Spagnoli,Mauriello,
Sangiorgi, Fratoni, Bonanno, Schwartz, Holmes.
Drafting of the manuscript: Mauriello, Sangiorgi,Fratoni,
Bonanno, Schwartz, Pistolese, Ippoliti, Holmes.
Critical revision of the manuscript for important
intellectual content: Spagnoli, Mauriello, Sangiorgi,Fratoni, Schwartz,
Statistical analysis: Mauriello.
Obtained funding: Spagnoli.
Administrative, technical, or material support:Fratoni,
Study supervision: Spagnoli, Mauriello, Schwartz,Holmes.
Funding/Support: This study was supported by
grant COFIN 2001 from MURST and the Mayo Foundation, Rochester, Minn.
Role of the Sponsors: MURST and the Mayo Foundation
did not participate in the design and conduct of the study, in the collection,
analysis, and interpretation of the data, or in the preparation, review, or
approval of the manuscript.
Acknowledgment: We thank William D. Edwards,
MD, for providing access to the Mayo specimens and Alfredo Colantoni, for
his helpful technical assistance.