Author Contributions: Dr Kidwell had full access
to all of the data in the study and takes full responsibility for the integrity
of the data and the accuracy of the data analysis.
Study concept and design: Kidwell, Chalela,
Saver, Starkman, Warach.
Acquisition of data: Kidwell, Chalela, Saver, Starkman,
Hill, Demchuk, Patronas, Alger, Latour, Baird, Leary, Tremwel, Ovbiagele,
Fredieu, Suzuki, Villablanca, Davis, Dunn, Todd, Ezzeddine, Haymore, Lynch,
Analysis and interpretation of data: Kidwell,
Chalela, Saver, Butman, Patronas, Alger, Latour, Luby, Villablanca, Davis,
Drafting of the manuscript: Kidwell, Chalela,
Fredieu, Davis Warach, Saver.
Critical revision of the manuscript for important
intellectual content: Kidwell, Chalela, Saver, Starkman, Hill, Demchuk,
Butman, Patronas, Alger, Latour, Luby, Baird, Leary, Tremwel, Ovbiagele, Suzuki,Villablanca,
Davis, Dunn, Todd, Ezzeddine, Haymore, Lynch, Davis, Warach.
Statistical analysis: Kidwell, Chalela, Saver,
Obtained funding: Kidwell, Saver, Warach.
Administrative, technical, or material support:
Kidwell, Saver, Starkman, Hill, Alger, Latour, Luby, Leary, Fredieu, Davis,
Todd, Haymore, Warach.
Study supervision: Kidwell, Chalela, Starkman,
Baird, Ezzeddine, Warach.
Funding/Support:This study was supported in
part by the Division of Intramural Research, National Institute of Neurological
Disorders and Stroke (NINDS) and grants from the American Heart Association
(0170033N, Dr Kidwell; AHA Western States Affiliate Fellowship Award, Dr Leary)
and NINDS (K23 NS 02088, Dr Kidwell; NS 39498/EB 002087, Dr Alger; K24 NS
02092, Dr Saver). Dr Hill was supported in part by the Heart & Stroke
Foundation of Alberta/NWT/NU and the Canadian Institutes for Health Research.
Role of the Sponsor: The study was wholly designed,
conducted, analyzed, and reported by the authors without any input from industrial
Acknowledgment: We would like to acknowledge
the invaluable assistance provided by Patricia Lyall, BA, Vickie Hyneman,
Elisa Landis, BA, and Sarah Hilton, BS, for the completion of this project.