0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Review | Clinician's Corner

Accuracy of Diagnostic Tests Read With and Without Clinical Information:  A Systematic Review

Clement T. Loy, MBBS, FRACP; Les Irwig, MBBCh, PhD
JAMA. 2004;292(13):1602-1609. doi:10.1001/jama.292.13.1602.
Text Size: A A A
Published online

Context Although it is common practice to read tests with clinical information, whether this improves or decreases the accuracy of test reading is uncertain.

Objective To determine whether diagnostic tests are more accurate when read with clinical information or without it.

Data Sources MEDLINE search (1966-December 2003) extended by search of reference lists and articles citing the articles retrieved (Web of Science, 1985-December 2003).

Study Selection All articles comparing the accuracy of tests read twice by the same readers, once without and once with clinical information, but otherwise under identical conditions. Only articles that reported sensitivity and specificity or receiver operating characteristic (ROC) curves were included.

Data Extraction Data were extracted by one author and reviewed independently by the other. When the data were difficult to interpret, differences were resolved by discussion.

Data Synthesis Sixteen articles met the inclusion criteria. Eleven articles compared areas under ROC curves for tests read with and without clinical information, and 5 compared only sensitivity and specificity. Ten articles used actual clinical information; 6 used constructed clinical information that was plausible. Overall, clinical information improved test reading accuracy although the effect was smaller in the articles using actual clinical information when compared with those using constructed clinical information. There were no instances in which clinical information resulted in significant reduction in test reading accuracy. In some instances, improved test reading accuracy came from improved sensitivity without loss of specificity.

Conclusions At least for the tests examined, the common practice of reading diagnostic tests with clinical information seems justified. Future studies should be designed to investigate the best way of providing clinical information. These studies should also give an estimate of the accuracy of clinical information used, display ROC curves with identified data points, and include a wider range of diagnostic tests.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Figures

Figure 1. Areas Under the Receiver Operating Characteristic Curve for Diagnostic Tests Read With or Without Clinical Information
Graphic Jump Location

Articles are presented in order by the difference in point estimates. For entries for which data reported were insufficient for calculation of confidence intervals, no error bars are displayed. Reported P values are for differences in areas under the receiver operating characteristic (ROC) curve in diagnostic tests read with or without clinical information. Some articles reported areas under the ROC curve for different subsets of readers or films. We have listed these subsets as separate entries in the display with descriptions for the subsets.
*Not significant with significance level set at P<.05.

Figure 2. Sensitivity and Specificity for Diagnostic Tests Read With or Without Clinical Information
Graphic Jump Location

All 5 articles used actual clinical information.

Tables

References

CME


You need to register in order to view this quiz.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

1,392 Views
66 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Jobs
JAMAevidence.com

Users' Guides to the Medical Literature

×
brightcove.createExperiences();