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The Rational Clinical Examination | Clinician's Corner

Does This Patient Have a Family History of Cancer?  An Evidence-Based Analysis of the Accuracy of Family Cancer History

Harvey J. Murff, MD, MPH; David R. Spigel, MD; Sapna Syngal, MD, MPH
JAMA. 2004;292(12):1480-1489. doi:10.1001/jama.292.12.1480.
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Context A family history of certain cancers is associated with an increased risk of developing cancer. Both cancer screening and genetic services referral decisions are often based on self-reported pedigree information.

Objective To determine the accuracy of self-reported family cancer history information.

Data Sources English-language articles were retrieved by searching MEDLINE (1966-June 2004) using Medical Subject Headings family, genetic predisposition to disease, medical history taking, neoplasm, and reproducibility of results. Additional articles were identified through bibliography searches.

Study Selection Original studies in which investigators validated self-reported family history by reviewing the identified relatives' medical records, death certificate, or cancer registry information were included, as well as studies that evaluated breast, colon, ovarian, endometrial, and prostate cancers.

Data Extraction Two of the 3 investigators independently reviewed and abstracted data for estimating the likelihood ratios (LRs) of self-reported family cancer history information. Only data from studies that evaluated both positive and negative family cancer histories were included within the analyses. A total of 14 studies met the search criteria and were included in the review.

Data Synthesis For patients without a personal history of cancer, the positive and negative LRs of a family history of the following cancers in a first-degree relative were 23.0 (95% confidence interval [CI], 6.4-81.0) and 0.25 (95% CI, 0.10-0.63) for colon cancer; 8.9 (95% CI, 5.4-15.0) and 0.20 (95% CI, 0.08-0.49) for breast cancer; 14.0 (95% CI, 2.2-83.4) and 0.68 (95% CI, 0.31-1.52) for endometrial cancer; 34.0 (95% CI, 5.7-202.0) and 0.51 (95% CI, 0.13-2.10) for ovarian cancer; and 12.3 (95% CI, 6.5-24.0) and 0.32 (95% CI, 0.18-0.55) for prostate cancer, respectively. Positive predictive values tended to be better in articles concerning first-degree relatives compared with second-degree relatives.

Conclusions Patient-reported family cancer histories for first-degree relatives are accurate and valuable for breast and colon cancer risk assessments. Negative family history reports for ovarian and endometrial cancers are less useful, although the prevalence of these malignancies within families is low.

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Figures

Figure. Hypothetical Pedigree for a Consultand With a Family History Suggestive of a Hereditary Nonpolyposis Colon Cancer
Graphic Jump Location
A consultand is an individual under evaluation for predicting his/her own future risk, or the risk of his/her offspring. The arrow identifies the consultand. The letter d. followed by a number (eg, d. 53) indicates the age the individual died and the 2-letter abbreviation with number (eg, Co 53) represents the diagnosis an individual received followed by the age at the time of diagnosis. This pedigree meets Amsterdam II criteria,14 which includes (1) 3 relatives with a hereditary nonpolyposis colorectal cancer–associated tumor, such as colon cancer, endometrial cancer, ureteral cancer, cancer of the renal pelvis, ovarian cancer, stomach cancer, or small bowel cancer; (2) one relative must be a first-degree relative of the other 2; (3) cancers affect at least 2 generations; and (4) 1 or more cases diagnosed before age 50 years.

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Original Article: Does This Patient Have a Family History of Cancer?

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