The concept of manipulation of the vascular bed to either increase or
decrease the number of blood vessels has attracted considerable interest.
This review focuses on angiogenesis as a therapeutic target, particularly
in the context of cancer and arthritis, as well as on promoting angiogenesis
in cardiovascular disease and the healing of bone fractures. Although once
touted almost as a panacea for treatment of tumors, as well as other diseases
associated with angiogenesis, such as diabetic retinopathy or rheumatoid arthritis,
it is now clear that such enthusiasm was somewhat premature. Similarly, some
clinical trials of therapeutic angiogenesis for the management of cardiovascular
disease have been disappointing. Nevertheless, this exciting field of research
holds promise for more targeted therapies.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 55
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.