Both high- and low-dose radiation exposures in women have been associated
with low-birth-weight offspring. It is unclear if radiation affects the hypothalamus-pituitary-thyroid
axis and thereby indirectly birth weight, or if the radiation directly affects
the reproductive organs.
To investigate whether antepartum dental radiography is associated with
A population-based case-control study.
Participants and Setting
Enrollees of a dental insurance plan with live singleton births in Washington
State between January 1993 and December 2000. Cases were 1117 women with low-birth-weight
infants (<2500 g), of whom 336 were term low-birth-weight infants (1501-2499
g and gestation ≥37 weeks). Four control pregnancies resulting in normal-birth-weight
infants (≥2500 g) were randomly selected for each case (n = 4468).
Main Outcome Measures
Odds of low birth weight and term low birth weight by dental radiographic
dose during gestation.
An exposure higher than 0.4 milligray (mGy) during gestation occurred
in 21 (1.9%) mothers of low-birth-weight infants and, when compared with women
who had no known dental radiography, was associated with an adjusted odds
ratio (OR) for a low-birth-weight infant of 2.27 (95% confidence interval
[CI], 1.11-4.66, P = .03). Exposure higher than 0.4
mGy occurred in 10 (3%) term low-birth-weight pregnancies and was associated
with an adjusted OR for a term low-birth-weight infant of 3.61 (95% CI, 1.46-8.92, P = .005).
Dental radiography during pregnancy is associated with low birth weight,
specifically with term low birth weight.