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Comment & Response |

Standard vs Enriched High Protein Enteral Nutrition in the ICU

Nikki Buijs, MD1; Paul A. M. van Leeuwen, MD, PhD1
[+] Author Affiliations
1Department of Surgery, VU University Medical Center, Amsterdam, the Netherlands
JAMA. 2014;312(21):2288-2289. doi:10.1001/jama.2014.14493.
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To the Editor Dr van Zanten and colleagues1 reported on a study of the effects of immune-enhancing nutrition involving patients in the intensive care unit; however, some of their statements on mortality are misleading.

First, the sample size of 300 was calculated based on a reduction in new infections from 25% to 12.5%. This is a reduction of 50%, not 12.5% as the authors stated. Is this a realistic reduction?


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December 3, 2014
Arthur R. H. van Zanten, MD, PhD; Zandrie Hofman, MSc
1Department of Intensive Care, Gelderse Vallei Hospital, Ede, the Netherlands
2Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, the Netherlands
JAMA. 2014;312(21):2288-2289. doi:10.1001/jama.2014.14499.
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